ODCs

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1 OMIM reference -
1 associated gene
14 signs/symptoms

PROTEIN INTERACTIONS: 2
COMMON SIGNS: 1

Keratosis palmoplantaris striata

3 OMIM references -
3 associated genes
4 signs/symptoms

Naxos disease

Keratosis palmoplantaris striata

JUP	(UniProt - OMIM)		DSG1	(UniProt - OMIM)
			DSP	(UniProt - OMIM)
			KRT1	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	JUP JUP	(0.93) (0.89)	DSG1 DSP

Citations in the biomedical literature:

Naxos disease		Keratosis palmoplantaris striata
	Synonym(s): - Keratosis palmoplantaris with arrythmogenic cardiomyopathy - Palmoplantar hyperkeratosis with arrythmogenic cardiomyopathy - Palmoplantar keratoderma with arrythmogenic cardiomyopathy		Synonym(s): - Keratosis palmoplantaris striata et areata - Keratosis palmoplantaris varians of Wachters - Striate palmoplantar keratoderma

	Classification (Orphanet): - Rare cardiac disease - Rare genetic disease - Rare skin disease		Classification (Orphanet): - Rare genetic disease - Rare skin disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: unknown Average age onset: neonatal/infancy Average age of death: no data available Type of inheritance: autosomal recessive		Epidemiological data: Class of prevalence: - Average age onset: - Average age of death: - Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - 1 MeSH reference: C538346		External references: 3 OMIM references - No MeSH references


COMMON SIGNS	- Palmoplantar hyperkeratosis / keratoderma

Naxos disease		Keratosis palmoplantaris striata
	Very frequent - Abnormal hair texture / hair dysplasia - Autosomal recessive inheritance - Cardiac rhythm disorder / arrhythmia - Cardiomyopathy / hypertrophic / dilated - Dizziness - Woolly / frizzy hair Frequent - Brittle hair / distrix / trichorrhexis - Cleft lip - Heart / cardiac failure - Hyperhidrosis / increased sweating - Hypotrichosis / atrichia / atrichiasis / scalp hairlessness Occasional - Acanthosis nigricans - Collapse / sudden death / cardiac arrest / cardiorespiratory arrest		Very frequent - Autosomal dominant inheritance Frequent - Hair and scalp anomalies - Nails anomalies